• Rheumatol. Int. · Jan 2012

    Case Reports

    Etanercept and anakinra can prolong febrile episodes in patients with hyperimmunoglobulin D and periodic fever syndrome.

    • Hiba M Shendi, Deirdre Walsh, and J David M Edgar.
    • Royal Victoria Hospital, Belfast, Northern Ireland, UK. hiba.shendi@belfasttrust.hscni.net
    • Rheumatol. Int. 2012 Jan 1; 32 (1): 249-51.

    AbstractHyperimmunoglobulin D and periodic fever syndrome (HIDS) is a rare, hereditary autoinflammatory condition, characterized by recurrent inflammatory episodes. There is no proven treatment for HIDS, but various drugs including, non-steroidal anti-inflammatory drugs, colchicine, steroids, statins and thalidomide have all been tried. Recently, some patients have demonstrated a good clinical response to either etanercept or anakinra. We report a case of a 10-year-old girl who experienced prolonged and severe inflammatory attacks, when she was treated with etanercept, and later with anakinra.

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