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Review
Use of chimeric antigen receptor T cells in allogeneic hematopoietic stem cell transplantation.
- Jun Liu, Xi Zhang, Jiang F Zhong, and Cheng Zhang.
- Department of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, People's Republic of China.
- Immunotherapy. 2019 Jan 1; 11 (1): 37-44.
AbstractThe chimeric antigen receptor T (CAR-T) cells play an antileukemia role, and can be used to treat or prevent relapse by targeting minimal residual disease for patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the infusion of allogeneic CAR-T cells may also cause graft-versus-host disease, which limited their applications during and after allo-HSCT. In this review, we discuss the clinical trials that applying CAR-T cells before allo-HSCT and the use of donor-derived CAR-T cells as conditioning regimen during allo-HSCT. At last, we analyzed the effect of donor-derived CAR-T cells on preventive infusion after allo-HSCT.
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