• Expert Opin Drug Deliv · Oct 2009

    Review

    New strategies to deliver anticancer drugs to brain tumors.

    • Valentino Laquintana, Adriana Trapani, Nunzio Denora, Fan Wang, James M Gallo, and Giuseppe Trapani.
    • Università degli Studi di Bari, Dipartimento Farmaco Chimico, Italy.
    • Expert Opin Drug Deliv. 2009 Oct 1; 6 (10): 1017-32.

    BackgroundMalignant brain tumors are among the most challenging to treat and at present there are no uniformly successful treatment strategies. Standard treatment regimens consist of maximal surgical resection followed by radiotherapy and chemotherapy. The limited survival advantage attributed to chemotherapy is partially due to low CNS penetration of antineoplastic agents across the blood-brain barrier (BBB).ObjectiveThe objective of this paper is to review recent approaches to delivering anticancer drugs into primary brain tumors.MethodsBoth preclinical and clinical strategies to circumvent the BBB are considered that include chemical modification and colloidal carriers.ConclusionAnalysis of the available data indicates that new approaches may be useful for CNS delivery, yet an appreciation of pharmacokinetic issues and improved knowledge of tumor biology will be needed to affect significantly drug delivery to the target site.

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