• Diagn. Microbiol. Infect. Dis. · Nov 2016

    Clinical utility of a nasal swab methicillin-resistant Staphylococcus aureus polymerase chain reaction test in intensive and intermediate care unit patients with pneumonia.

    • Stephanie E Giancola, Ai Thi Nguyen, Binh Le, Omar Ahmed, Catherine Higgins, James A Sizemore, and Kara W Orwig.
    • St. Mary's Medical Center, Huntington, WV, USA. Electronic address: steph.giancola@gmail.com.
    • Diagn. Microbiol. Infect. Dis. 2016 Nov 1; 86 (3): 307-310.

    AbstractThis retrospective study aimed to validate the concordance between nasal swab methicillin-resistant Staphylococcus aureus (MRSA) polymerase chain reaction (PCR) test and respiratory culture and to determine the number of potentially preventable days of anti-MRSA therapy in patients with pneumonia. Two hundred adult inpatients in the intensive and intermediate care units were included. The nasal swab MRSA PCR test was positive in 55 (27.5%) patients. MRSA was isolated from respiratory culture in 21 (10.5%) patients. The nasal swab MRSA PCR test demonstrated 90.5% sensitivity, 79.9% specificity, 34.5% positive predictive value, and 98.6% negative predictive value. Anti-MRSA therapy was initiated in 168 (84%) patients. Patients in the study received a combined 782days of anti-MRSA therapy; 300days were considered potentially preventable. This study suggests that the nasal swab MRSA PCR test may be used to guide discontinuation of anti-MRSA antibiotics in patients with clinically confirmed pneumonia in the intensive or intermediate care units.Published by Elsevier Inc.

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