• J Subst Abuse Treat · Aug 2014

    Meta Analysis Comparative Study

    Extended-release naltrexone for alcohol and opioid dependence: a meta-analysis of healthcare utilization studies.

    • Daniel M Hartung, Dennis McCarty, Rongwei Fu, Katharina Wiest, Mady Chalk, and David R Gastfriend.
    • Oregon State University/Oregon Health & Science University College of Pharmacy, 3303 SW Bond Avenue, CH12C, Portland OR 97239. Electronic address: hartungd@ohsu.edu.
    • J Subst Abuse Treat. 2014 Aug 1; 47 (2): 113-21.

    AbstractThrough improved adherence, once-monthly injectable extended-release naltrexone (XR-NTX) may provide an advantage over other oral agents approved for alcohol and opioid dependence treatment. The objective of this study was to evaluate cost and utilization outcomes between XR-NTX and other pharmacotherapies for treatment of alcohol and opioid dependence. Published studies were identified through comprehensive search of two electronic databases. Studies were included if they compared XR-NTX to other approved medicines and reported economic and healthcare utilization outcomes in patients with opioid or alcohol dependence. We identified five observational studies comparing 1,565 patients using XR-NTX to other therapies over 6 months. Alcohol dependent XR-NTX patients had longer medication refill persistence versus acamprosate and oral naltrexone. Healthcare utilization and costs was generally lower or as low for XR-NTX-treated patients relative to other alcohol dependence agents. Opioid dependent XR-NTX patients had lower inpatient substance abuse-related utilization versus other agents and $8170 lower total cost versus methadone.Copyright © 2014 Elsevier Inc. All rights reserved.

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