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Ugeskrift for laeger · Oct 2010
[Treatment of neuroendocrine tumours of the gastrointestinal tract].
- Carsten Palnaes Hansen, Seppo Langer, Susanne Frevert, Jann Mortensen, Andreas Kjaer, and Ulrich Knigge.
- Kirurgisk Klinik C, Rigshospitalet, 2100 København Ø, Denmark. city@oncable.dk
- Ugeskr. Laeg. 2010 Oct 25; 172 (43): 2942-5.
AbstractThe prognosis of neuroendocrine tumours of the gastrointestinal tract and pancreas is difficult to estimate due to their heterogeneous nature. Survival without dissemination may reach 90%, while metastases reduce the 5-year survival to less than 50%. Radical surgery offers the only possibility of cure. Palliative therapy includes surgery and intra-arterial embolization of hepatic metastases, chemotherapy, biotherapy with interferon-alpha and radionuclear treatment. Tumour-targeted therapy with tyrosine kinase inhibitors, mammalian target of rapamycin inhibitors or monoclonal antibodies are under investigation in phase-III studies.
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