• Minerva endocrinologica · Dec 2001

    Review

    [Somatostatin analogues for the treatment of gastro-entero-pancreatic neuroendocrine tumours].

    • G Uomo, D Germano, and P G Rabitti.
    • III Divisione, Medicina Interna, Azienda Ospedaliera di Rilievo Nazionale, A. Cardarelli, Naples, Italy. uomogir@liberto.it
    • Minerva Endocrinol. 2001 Dec 1; 26 (4): 225-9.

    AbstractSomatostatin has represented a significant breakthrough in the treatment of patients with hormone-acting, neuroendocrine gastro-intestinal-pancreatic (NEGEP) neoplasms, even if its short half-life made it impractical in the clinical practice. Over the last recent years new long-acting formulations have been developed from the native peptide. Octreotide, lanreotide and vapeotide are octapeptides with similar biological activity, remarkable stability and longer half-life; an extended-release formulation of octreotide (Octreotide-LAR) and lanreotide (Lanreotide-SR) have been more recently developed by incorporating the peptide in microspheres of a biodegradable polymer. This formulation was conceived to provide patients with the convenience of a once-a-month or twice-a-month injection and to ensure a stable serum concentration between injections and good clinical control of NEGEP tumours symptoms. Nowadays, somatostatin long-acting analogues represent the first treatment option in those patients who doesn't underwent radical surgery; in addition, these substances present no important side effects, ameliorate the prognosis and can exert some degree of tumour growth control.

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