• Acta Pharmacol. Sin. · Nov 2000

    Sympathectomy induces novel purinergic sensitivity in sciatic afferents.

    • Y Chen, Y H Zhang, B H Bie, and Z Q Zhao.
    • Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031, China.
    • Acta Pharmacol. Sin. 2000 Nov 1; 21 (11): 1002-4.

    AimTo test the hypothesis that sympathectomy could induce novel purinergic sensitivity in sciatic afferents.MethodsTeased-fiber recordings were made from 32 spontaneously active A afferents from the sciatic nerves in surgically sympathectomized rats and 30 spontaneously active A afferents from the sciatic nerves in intact rats. Adenosine 5'-triphosphate (ATP) was injected via a cannula in jugular vein.ResultsTwenty eight percent of the spontaneously active afferent fibers from sciatic nerves in the sympathectomized rats responded to ATP, either with an increase or with a decrease in spontaneous firing. However, none of the fibers from the sciatic nerves in the intact rats was activated by ATP.ConclusionSympathectomy induces novel purinergic sensitivity in A afferents from sciatic nerve.

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