• Frontiers in immunology · Jan 2020

    Review

    Will Hydroxychloroquine Still Be a Game-Changer for COVID-19 by Combining Azithromycin?

    • Chunfeng Li and Genhong Cheng.
    • Institute for Immunity, Transplantation, and Infection, School of Medicine, Stanford University, Stanford, CA, United States.
    • Front Immunol. 2020 Jan 1; 11: 1969.

    AbstractRecent small-scale clinical trials have shown promising results in the use of hydroxychloroquine, an FDA approved anti-malaria drug, for the treatment of COVID-19. However, large scale, randomized and double-blind clinical trials are needed to confirm the safety and efficacy of hydroxychloroquine in COVID-19 patients. Here, we review the progress of using hydroxychloroquine or chloroquine as anti-viral agents, failed clinical trials of chloroquine in treatment of dengue virus and influenza infection, and especially the mechanism of azithromycin in inhibiting viral replication, so as to shed light on the ongoing clinical trials and further researches of hydroxychloroquine on SARS-CoV-2 infected patients.Copyright © 2020 Li and Cheng.

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