-
- Cem Akin.
- Mastocytosis Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: cakin@partners.org.
- J Allergy Clin Immunol Pract. 2014 May 1; 2 (3): 252-7.e1; quiz 258.
AbstractDisorders associated with mast cell activation range from relatively common IgE-mediated disease and chronic urticaria to rarer conditions such as mastocytosis or monoclonal mast cell activation disorder. Mast cell activation disorders can be mechanistically classified into primary (associated with abnormal production of mast cells that carry pathologic markers of clonality), secondary (normal mast cells activated in reaction to a microenvironmental trigger), and idiopathic (no etiology is found). Clinical presentations, diagnostic criteria as well as general principles of a stepwise therapy approach are discussed. Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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