• Sylvain Ladoire, Vincent Goussot, Emilie Redersdorff, Adele Cueff, Elise Ballot, Caroline Truntzer, Siavoshe Ayati, Leila Bengrine-Lefevre, Nathalie Bremaud, Bruno Coudert, Isabelle Desmoulins, Laure Favier, Cléa Fraisse, Jean-David Fumet, Roxana Hanu, Audrey Hennequin, Alice Hervieu, Silvia Ilie, Courèche Kaderbhai, Aurélie Lagrange, Nils Martin, Irina Mazilu, Didier Mayeur, Rémi Palmier, Anne-Laure Simonet-Lamm, Julie Vincent, Sylvie Zanetta, Laurent Arnould, Charles Coutant, Aurélie Bertaut, and François Ghiringhelli.
• Department of Medical Oncology, Centre Georges François Leclerc, Dijon, France; Research Platform in Biological Oncology, Georges François Leclerc Cancer Center, Dijon, France; Centre de Recherche INSERM LNC-UMR1231, Dijon, France; University of Burgundy-Franche Comté, France. Electronic address: sladoire@cgfl.fr.
• Eur. J. Cancer. 2021 May 1; 148: 359-370.

BackgroundIn view of the potential gravity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection for patients with cancer, epidemiological data are vital to assess virus circulation among patients and staff of cancer centres. We performed a prospective study to investigate seroprevalence of SARS-CoV-2 antibodies among staff and patients with cancer at a large cancer centre, at the end of the period of first national lockdown in France and to determine factors associated with the risk of SARS-CoV-2 infection.MethodsAfter the first lockdown, all medical and non-medical staff, as well as all patients attending the medical oncology department were invited to undergo serological testing for SARS-CoV-2 between 11 May and 30 June 2020. All participants were also invited to complete a questionnaire collecting data about their living and working conditions, and for patients, medical management during lockdown.FindingsA total of 1,674 subjects (663 staff members, 1011 patients) were included. Seroprevalence was low in both staff (1.8%) and patients (1.7%), despite more features of high risk for severe forms among patients. None of the risk factors tested in our analysis (working or living conditions, comorbidities, management characteristics during lockdown) was found to be statistically associated with seroprevalence in either staff or patients. There was no significant difference in the proportion of symptomatic and asymptomatic subjects between staff and patients. Only fever, loss of smell, and loss of taste were significantly more frequent among seropositive patients, in both staff and patients.InterpretationWe report very low seroprevalence of antibodies against SARS-CoV-2 in the staff (caregiving and non-caregiving) and patients of a large cancer care centre in which strict hygiene, personal protection, and social distancing measures were implemented.Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

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