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J Bone Joint Surg Br · Jan 1996
Systemic release of cobalt and chromium after uncemented total hip replacement.
- D N Kreibich, C G Moran, H T Delves, T D Owen, and I M Pinder.
- Freeman Hospital, Newcastle upon Tyne and Southampton General Hospital, England.
- J Bone Joint Surg Br. 1996 Jan 1; 78 (1): 18-21.
AbstractWe measured the levels of cobalt and chromium in the serum in three groups of patients after uncemented porous-coated arthroplasty. Group 1 consisted of 14 consecutive patients undergoing revision for aseptic loosening. Group 2 comprised 14 matched patients in whom the arthroplasty was stable and group 3 was 14 similarly matched patients with arthritis awaiting hip replacement. Specimens were analysed using atomic absorption spectrophotometry. Aseptic loosening of a component resulted in a significant elevation of serum cobalt (p < 0.05), but not of serum chromium. The relative risk of a component being loose, if the patient had a serum cobalt greater than 9.0 nmol/l, was 2.8.
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