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Ann. N. Y. Acad. Sci. · Dec 2004
Oxidative stress and changes in alpha- and gamma-tocopherol levels during coronary artery bypass grafting.
- A T Ulus, A Aksoyek, M Ozkan, S F Katircioglu, B Vessby, and S Basu.
- Sections of Geriatrics and Clinical Nutrition Research, Faculty of Medicine, Uppsala University, Uppsala, Sweden.
- Ann. N. Y. Acad. Sci. 2004 Dec 1; 1031: 352-6.
AbstractWe studied whether cardiopulmonary bypass (CPB) has any immediate impact on the initiation of antioxidative defenses in the body by measuring F(2)-isoprostanes and alpha- and gamma-tocopherol, respectively. 8-iso-PGF(2alpha) levels increased significantly within 3 minutes and until the end of CPB. alpha-Tocopherol levels increased gradually at 20 min during CPB and continued until 6 hours after CPB. gamma-Tocopherol levels followed a similar fashion at the end of CPB. 8-iso-PGF(2alpha) and tocopherol levels kept at basal level 12 and 24 hours post CPB. These findings suggest that an increased free radical-induced oxidative stress together with a gradual appearance of antioxidative defense system during and after CPB.
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