• S Kubilay Pakin, Jian Xu, Mark E Schweitzer, and Ravinder R Regatte.
• Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA. pakin@med.nyu.edu
• Magn Reson Med. 2006 Sep 1; 56 (3): 563-71.

AbstractThree-dimensional spin-lattice relaxation time in the rotating frame (3D-T1rho) with parallel imaging at 3.0T was implemented on a whole-body clinical scanner. A 3D gradient-echo sequence with a self-compensating spin-lock pulse cluster was combined with generalized autocalibrating partially parallel acquisitions (GRAPPA) to acquire T1rho-weighted images. 3D-T1rho maps of an agarose phantom and three healthy subjects were constructed using an eight-channel phased-array coil without parallel imaging and with parallel imaging acceleration factors of 2 and 3, in order to assess the reproducibility of the method. The coefficient of variation (CV) of the median T1rho of the agarose phantom was 0.44%, which shows excellent reproducibility. The reproducibility of in vivo 3D-T1rho maps was also investigated in three healthy subjects. The CV of the median T1rho of the patellar cartilage varied between approximately 1.1% and 4.3%. Similarly, the CV varied between approximately 2.1-5.8%, approximately 1.4-8.7%, and approximately 1.5-4.1% for the biceps femoris and lateral and medial gastrocnemius muscles, respectively. The preliminary results demonstrate that 3D-T1rho maps can be constructed with good reproducibility using parallel imaging. 3D-T1rho with parallel imaging capability is an important clinical tool for reducing both the total acquisition time and RF energy deposition at 3T.Copyright (c) 2006 Wiley-Liss, Inc.

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