• Blood · Aug 1999

    Real-time analysis of mural thrombus formation in various platelet aggregation disorders: distinct shear-dependent roles of platelet receptors and adhesive proteins under flow.

    • S Tsuji, M Sugimoto, S Miyata, M Kuwahara, S Kinoshita, and A Yoshioka.
    • Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan; and Higashi-Osaka General Hospital, Higashi-Osaka, Osaka, Japan.
    • Blood. 1999 Aug 1; 94 (3): 968-75.

    AbstractWe evaluated real-time processes of platelet thrombus formation on a collagen surface in a flow chamber with whole blood from patients with various platelet aggregation disorders, such as Bernard-Soulier syndrome (BSS), Glanzmann's thrombasthenia (GTA), type 3 von Willebrand disease (vWD), and congenital afibrinogenemia (Af), who lack platelet glycoprotein (GP) Ib-IX complex, GP IIb-IIIa, von Willebrand factor (vWF), and fibrinogen, respectively. Blood from GTA patients showed impaired thrombus growth but significant initial platelet-surface interaction under all shear conditions tested (50 to 1,500 s(-1)). By contrast, blood from patients with BSS or type 3 vWD showed no platelet-surface interaction under high shear (>/=1, 210 s(-1)) but normal thrombus formation under low shear (

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