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- P Beuzeboc, S Scholl, X S Garau, A Vincent-Salomon, P D Cremoux, J Couturier, T Palangié, and P Pouillart.
- Service d'oncologie médicale, Institut Curie, 26, rue d'Ulm, 75005 Paris.
- Bull Cancer. 1999 Jun 1; 86 (6): 544-9.
AbstractHER2 is overexpressed in about 25% to 30% of breast cancers and associated with poor prognosis, resistance to hormonotherapy and lack of sensitivity to CMF-based adjuvant chemotherapy. Herceptin (trastuzumab), a humanized monoclonal antibody, administered as a single agent, produces objective responses in phase II trials in patients with metastatic breast cancers overexpressing HER2. It has shown a substantial benefit in a phase III trial which compares a standard first line chemotherapy (doxorubicin and cyclophosphamide or taxol alone) to the same chemotherapy with Herceptin in metastatic breast cancer. The Herceptin arm had significantly higher response rate (+ 53%), an improvement in the median duration of response (+ 57%) as well as in time to progression (+ 65%) compared to chemotherapy alone.
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