• Int J Mol Sci · Nov 2018

    Review

    The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis.

    • Akira Saito, Masafumi Horie, Patrick Micke, and Takahide Nagase.
    • Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. asaitou-tky@umin.ac.jp.
    • Int J Mol Sci. 2018 Nov 15; 19 (11).

    AbstractIdiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)-β signaling plays a central role in tissue fibrosis and tumorigenesis. TGF-β-mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF-β signaling.

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