• Jeong Ku Ha, Jin Seong Kim, Joo Young Kim, Jong Bok Yun, Yun Young Kim, and Kyu Sung Chung.
• Department of Orthopedic Surgery and Sports Medical Center and Sports Medical Research Institute, Seoul Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.
• Medicine (Baltimore). 2021 Jul 2; 100 (26): e26542e26542.

BackgroundGreenCross Wellbeing Corporation (GCWB) 106 is a food item based on Chrysanthemum zawadskii var. latilobum extract. It has an inhibitory effect on joint inflammation.ObjectiveThis study investigated the efficacy and safety of GCWB106 for osteoarthritis (OA) of the knee joint.MethodsOverall, 121 participants with mild OA were recruited and randomly divided into two groups. One group received GCWB106 for 12 weeks and the other group received placebo for 12 weeks. Outcomes were evaluated using the Korean-Western Ontario and McMaster Universities Index (K-WOMAC), visual analog scale, Korean Short Form Health Survey 36 score, and laboratory test results.ResultsAfter 12 weeks of study treatment, the GCWB106 group exhibited a significant improvement compared with the placebo group in overall K-WOMAC score (P = .042) and K-WOMAC physical function score (P = .015). The GCWB106 group showed significant improvement in the visual analog scale pain score (P < .001) compared with the placebo group after 6 weeks and 12 weeks; no adverse drug reactions or serious adverse events were reported in either group.ConclusionGCWB106 can safely reduce pain and improve knee function with therapeutic effects in OA of the knee joint.Level Of EvidenceRandomized, double-blind, placebo-controlled clinical study, Level I.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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