• Blood Coagul. Fibrinolysis · Apr 2001

    Case Reports

    Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa.

    • K Meijer, F T Peters, and J van der Meer.
    • Division of Haemostasis, Thrombosis and Rheology, University Hospital Groningen, The Netherlands. karinameijer@hetnet.nl
    • Blood Coagul. Fibrinolysis. 2001 Apr 1; 12 (3): 211-3.

    AbstractA patient with von Willebrand's disease had recurrent gastrointestinal bleeding from angiodysplasia, with inadequate response to von Willebrand factor substitution, medical and endoscopic treatment, and resection of affected bowel. Frequent blood transfusions were required. She started home treatment with recombinant activated factor VII (rFVIIa) at the onset of bleeding, in addition to her standard therapy. From then on, bleeds could be controlled rapidly and no more blood transfusions were needed. We conclude that rFVIIa is effective in this case of angiodysplasia and might be a therapeutic option in similar patients.

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