• Therap Adv Gastroenterol · Jan 2019

    Review

    Management of Clostridioides difficile colitis: insights for the gastroenterologist.

    • Srishti Saha and Sahil Khanna.
    • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
    • Therap Adv Gastroenterol. 2019 Jan 1; 12: 1756284819847651.

    AbstractClostridioides difficile infection (CDI) is a common cause of diarrhea in both inpatient and outpatient settings. The last few years have seen major changes in the treatment spectrum of CDI, most notably, recommendations against using metronidazole for initial CDI, the addition of fidaxomicin and bezlotoxumab, and emergence of microbial replacement therapies. Several other therapies are undergoing clinical trials. This narrative review focuses on the treatment of CDI with a summary of literature on the newer modalities and the treatment guidelines issued by Infectious Diseases Society of America and European Society of Clinical Microbiology and Infectious Diseases.

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