• Clinical rheumatology · Mar 2014

    Case Reports

    Pneumocystis jirovecii pneumonia in two patients with systemic lupus erythematosus after rituximab therapy.

    • F Bonilla-Abadía, J F Betancurt, J C Pineda, J D Vélez, G J Tobón, and C A Cañas.
    • Rheumatology Unit, Cra. 98N. 18-49, Fundación Valle del Lili-ICESI University, Cali, Colombia.
    • Clin. Rheumatol. 2014 Mar 1; 33 (3): 415-8.

    AbstractNew cases of Pneumocystis jirovecii pneumonia (PJP) have recently been reported in patients with systemic lupus erythematosus (SLE) after rituximab therapy. Several factors may contribute to susceptibility to P. jirovecii infection in this type of patients, including the immunological characteristics of the disease, the mechanisms of rituximab action, environmental factors, and the biological characteristics of the fungus. We report two patients with SLE who developed PJP after rituximab therapy.

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