• Future oncology · Jan 2015

    Review

    Olaparib: an oral PARP-1 and PARP-2 inhibitor with promising activity in ovarian cancer.

    • Camille C Gunderson and Kathleen N Moore.
    • University of Oklahoma Health Sciences Center, Stephenson Oklahoma Cancer Center, 800 NE 10th Street, Suite 5040, Oklahoma City, OK 73104, USA.
    • Future Oncol. 2015 Jan 1; 11 (5): 747-57.

    AbstractOlaparib (Lynparza™; AZD2281) is a potent PARP-1 and PARP-2 inhibitor with biologic activity in ovarian cancer as well as other solid tumors. It has been tested in Phase I and II trials and has single-agent activity in both germline BRCA mutated and sporadic ovarian cancer. Phase III trials assessing the efficacy of olaparib in the maintenance setting following first line and platinum-sensitive recurrence are underway for patients with a germline BRCA mutation, given the inherent molecular compatibility with the drug's mechanism of action.

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