• Curr. Med. Chem. · Jan 2005

    Review

    Inhibition of p450 17 as a new strategy for the treatment of prostate cancer.

    • F Leroux.
    • Laboratoire de Stéréochimie associé au CNRS (UMR CNRS 7509), Université Louis Pasteur (ECPM), Strasbourg, France. lerouxf@ecpm.u-strasbg.fr
    • Curr. Med. Chem. 2005 Jan 1; 12 (14): 1623-9.

    AbstractThe cytochrome P450 monooxygenase enzyme system is involved in the synthesis and/or degradation of a large number of endogenous compounds and in the biotransformation of drugs and other xenobiotics. 17alpha-Hydroxylase-C17,20-lyase (P450 17, CYP 17) is the key enzyme of the androgen biosynthesis. As androgens have been implicated in the development and progression of prostate cancer, this enzyme has become a promising therapeutic target. This paper will review the possible approaches dealing with P450 17 inhibition as a chemotherapeutic strategy in the struggle against prostate cancer.

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