• Huanzhou Yu, Charles A McKenzie, Ann Shimakawa, Anthony T Vu, Anja C S Brau, Philip J Beatty, Angel R Pineda, Jean H Brittain, and Scott B Reeder.
• Global Applied Science Lab, GE Healthcare, Menlo Park, California, USA. Huanzhou.Yu@ge.com
• J Magn Reson Imaging. 2007 Oct 1; 26 (4): 1153-61.

PurposeTo describe and demonstrate the feasibility of a novel multiecho reconstruction technique that achieves simultaneous water-fat decomposition and T2* estimation. The method removes interference of water-fat separation with iron-induced T2* effects and therefore has potential for the simultaneous characterization of hepatic steatosis (fatty infiltration) and iron overload.Materials And MethodsThe algorithm called "T2*-IDEAL" is based on the IDEAL water-fat decomposition method. A novel "complex field map" construct is used to estimate both R2* (1/T2*) and local B(0) field inhomogeneities using an iterative least-squares estimation method. Water and fat are then decomposed from source images that are corrected for both T2* and B(0) field inhomogeneity.ResultsIt was found that a six-echo multiecho acquisition using the shortest possible echo times achieves an excellent balance of short scan and reliable R2* measurement. Phantom experiments demonstrate the feasibility with high accuracy in R2* measurement. Promising preliminary in vivo results are also shown.ConclusionThe T2*-IDEAL technique has potential applications in imaging of diffuse liver disease for evaluation of both hepatic steatosis and iron overload in a single breath-hold.(c) 2007 Wiley-Liss, Inc.

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