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J. Pediatr. Hematol. Oncol. · Mar 2021
Multimodal Analgesic Plan for Children Undergoing Chimeric 14.18 Immunotherapy.
- Gianluca Bertolizio, Annik Otis, Karen Tam, Swapnil Aswar, Marta Garbin, and Pablo Ingelmo.
- Department of Anesthesia.
- J. Pediatr. Hematol. Oncol. 2021 Mar 1; 43 (2): e169-e172.
AbstractImmunotherapy with the chimeric 14.18 anti-GD2 antibody (ch14.18) is associated with severe neuropathic pain. Different analgesic modalities have been employed, but pain management remains challenging and side effects such as desaturation, bradycardia, and hypotension have been reported. We retrospectively analyzed the efficacy of a multimodal regimen based on gabapentin, ketamine, and morphine in controlling pain during ch14.18 chemotherapy. In our cohort, the pain was low, desaturation and hypotension were infrequent, and no episode of bradycardia was reported. Morphine consumption was similar to other studies. Our results suggest that this regimen may be a valid analgesic option in children undergoing ch14.18 infusion.Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
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