• Annals of medicine · Dec 2021

    The role of lycopene for the amelioration of glycaemic status and peripheral antioxidant capacity among the Type II diabetes mellitus patients: a case-control study.

    • Hui Eng Leh, Mastura Mohd Sopian, Mohamad Hafizi Abu Bakar, and Lai Kuan Lee.
    • Food Technology Program, School of Industrial Technology, Universiti Sains Malaysia, Gelugor, Pulau Pinang, Malaysia.
    • Ann. Med. 2021 Dec 1; 53 (1): 105910651059-1065.

    BackgroundThe use of lycopene as a complementary medicine for Type II diabetes mellitus (T2DM) is limited and controversial. This study evaluated the effect of lycopene intake on the changes of glycaemic status and antioxidant capacity among the T2DM patients.Patients And MethodsThis case-control study involved the participation of 87 patients and 122 healthy individuals. Lycopene intake was assessed by using a food frequency questionnaire. The peripheral antioxidant capacity among the T2DM patients was evaluated. Glycated haemoglobin (HbA1c) and fasting plasma glucose (FPG) were measured as indications of glycaemic status.ResultsPeripheral antioxidant capacity was significantly lower in the T2DM group. Direct positive correlations were found between the lycopene intake and peripheral antioxidant level among the T2DM patients. Contrarily, HbA1c and FPG levels decreased significantly with the higher lycopene intake.ConclusionsT2DM patients with a higher lycopene intake showed a greater peripheral antioxidant capacity and better glycaemic control. Lycopene may act to ameliorate oxidative stress and improve the pathophysiology of T2DM.

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