• Bisakh Bhattacharya, Rohit Kumar, Ved Prakash Meena, Manish Soneja, Amit Singh, Rojaleen Das, Ashit Xess, Nazneen Arif, Saurabh Vig, Vandana Rastogi, Pavan Tiwari, Sushma Bhatnagar, Anant Mohan, Naveet Wig... more , and Lalit Dar. less
• Department of Medicine, All India Institute of Medical Sciences, Medicine Office, 3rd floor, Teaching block, AIIMS, New Delhi, India.
• Pathog Dis. 2021 Jan 9; 79 (1).

Backgrounddespite being in the 5th month of pandemic, knowledge with respect to viral dynamics, infectivity and RT-PCR positivity continues to evolve.Aimto analyse the SARS CoV-2 nucleic acid RT-PCR profiles in COVID-19 patients.Designit was a retrospective, observational study conducted at COVID facilities under AIIMS, New Delhi.Methodspatients admitted with laboratory confirmed COVID-19 were eligible for enrolment. Patients with incomplete details, or only single PCR tests were excluded. Data regarding demographic details, comorbidities, treatment received and results of SARS-CoV-2 RT-PCR performed on nasopharyngeal and oropharyngeal swabs, collected at different time points, was retrieved from the hospital records.Resultsa total of 298 patients were included, majority were males (75·8%) with mean age of 39·07 years (0·6-88 years). The mean duration from symptom onset to first positive RT-PCR was 4·7 days (SD 3·67), while that of symptom onset to last positive test was 17·83 days (SD 6·22). Proportions of positive RT-PCR tests were 100%, 49%, 24%, 8·7% and 20·6% in the 1st, 2nd, 3rd, 4th and >4 weeks of illness. A total of 12 symptomatic patients had prolonged positive test results even after 3 weeks of symptom onset. Age > = 60 years was associated with prolonged RT-PCR positivity (statistically significant).Conclusionthis study showed that the average period of PCR positivity is more than 2 weeks in COVID-19 patients; elderly patients have prolonged duration of RT-PCR positivity and requires further follow up.© The Author(s) 2020. Published by Oxford University Press on behalf of FEMS.

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