• María Fernández-Prada, Paula García-González, Alejandro García-Morán, Inés Ruiz-Álvarez, Covadonga Ramas-Diez, and Carmen Calvo-Rodríguez.
• Servicio de Medicina Preventiva y Salud Pública, Hospital Vital Álvarez Buylla, Servicio de Salud del Principado de Asturias, Asturias, España. Electronic address: mariafdezprada@gmail.com.
• Med Clin (Barc). 2021 Sep 10; 157 (5): 226233226-233.

Background And ObjectiveSARS-CoV-2 has been and is a major global Public Health challenge. Since the beginning of the pandemic, different comorbidities have been postulated and associated with spectra of increased severity and mortality. The objectives of this research are: 1) to analyse the factors associated with SARS-CoV-2 infection (COVID-19) in a health area in northern Spain; 2) to understand the possible role of influenza vaccination and pneumococcal vaccination in the development of COVID-19.Materials And MethodA test-negative case-control study was conducted. Variables related to personal and vaccination history were considered. Although the epidemiological definition of the case varied over time, the reference definition was that corresponding to 31/01/2020 in Spain. A bivariate and multivariate analysis was performed.ResultsThe sample included 188 patients, of which 63 were cases and 125 controls. The results show that obesity increases the risk 2.4-fold of suffering this infection (IC 95% 1,301-4,521) and ARA-2 increases it 2.2-fold (95% CI 1,256-6,982). On the other hand, anti-pneumococcal vaccination of 13 serotypes showed results close to statistical significance (OR = 0.4; 95% CI 0.170-1,006).ConclusionObesity and the use of ARA-2 increases the risk of COVID-19. Scientific knowledge about factors associated with COVID-19 should be expanded. The authors consider that the present research raises the need further investigate the role of vaccines in this infection and their possible heterologous properties.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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