• Guihua Tang, Wen Yin, and Wenen Liu.
• Department of Clinical Laboratory, Xiangya Hospital of Central South University, 410008, Changsha, China. Electronic address: 13974892471@163.com.
• Diagn. Microbiol. Infect. Dis. 2017 Aug 1; 88 (4): 322-329.

AbstractFecal microbiota transplantation (FMT) is a remarkably efficacious therapy for recurrent or refractory Clostridium difficile infection (CDI), but not standardized. This work is to determine whether frozen FMT is as effective as fresh FMT. Meta-analysis showed that frozen FMT was as effective as fresh FMT, both pooled first effective rate (65.0% (95% CI 57.0-73.0%) vs. 65.0% (95% CI 57.0-73.0%), P=0.962) and pooled second effective rate (95.0% (95% CI 91.0-99.0%) vs. 95.0% (95% CI 92.0-99.0%), P=0.880). In conclusion, among patients with recurrent or refractory CDI, frozen FMT is as effective as fresh FMT. Considering potential advantages of performing frozen FMT, it is a reasonable option to select frozen FMT.Copyright © 2017 Elsevier Inc. All rights reserved.

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