• Anasthesiol Intensivmed Notfallmed Schmerzther · May 2021

    [Vitamin C - New Option in Sepsis Therapy?]

    • Stefan Müller, Thomas Wiesmann, Hinnerk Wulf, and Christian Arndt.
    • Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 May 1; 56 (5): 374-382.

    AbstractVitamin C deficiency often occurs in critical illness and especially in patients with sepsis. Low plasma levels correlate with organ dysfunction and outcome parameters. Vitamin C offers pleiotropic effects possibly attenuating pathophysiology in sepsis. This includes antioxidative effects like scavenging reactive oxygen species or restoring other antioxidants. Vitamin C is a cofactor for norepinephrine biosynthesis and it protects endothelial function. In addition, it modulates immune response. A combined therapy with vitamin C, hydrocortisone and thiamine could be beneficial because of synergistic effects. Some clinical studies have shown reduced mortality due to vitamin C alone or in combination with hydrocortisone and thiamine, others do not. Adverse events are rare. So data supporting a therapy with vitamin C is still unclear. Further randomised controlled trials are necessary.Thieme. All rights reserved.

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