• Herminia Lozano Gómez, Ana Pascual Bielsa, Paula Abansés Moreno, María Pilar Luque Gómez, Almudena Matute Guerrero, and Juan José Araiz Burdio.
• Servicio de Medicina Intensiva, Hospital Clínico Universitario Lozano Blesa, Zargoza, España. Electronic address: fiex_hermi1990@hotmail.com.
• Med Clin (Barc). 2021 Aug 13; 157 (3): 141143141-143.

IntroductionIn the context of the global COVID-19 pandemic, the different clinical manifestations of this infection pose a challenge for healthcare professionals. Respiratory involvement, the main symptom of SARS-CoV-2 infection, means that other manifestations, such as neurological, take a back seat, with the consequent delay in diagnosis and treatment.Material And MethodsAll COVID-19 patients admitted with neurological symptoms or diagnosed with encephalitis since March 2020 in a tertiary hospital in Zaragoza, Spain.ResultsTwo patients with COVID-19 infection confirmed by nasopharyngeal PCR and whose clinical picture consisted of neurological alterations compatible with encephalitis. Cerebrospinal fluid (CSF) microbiology was negative for bacteria and viruses, including SARS-CoV-2 but, given the clinical suspicion of encephalitis due to the latter, antiviral treatment with immunoglobulins and plasmapheresis was started early. Despite this, the evolution was not satisfactory.ConclusionsCOVID-19 encephalitis is a recently described clinical entity, whose pathophysiology is still unknown and no treatment with clinical evidence is available to date.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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