• Coronary artery disease · Mar 2017

    Review

    Acute coronary syndromes in patients with HIV.

    • Valmiki K Seecheran, Stanley L Giddings, and Naveen A Seecheran.
    • aDepartment of Adult Medicine, The University of the West Indies, St. Augustine bDepartment of Adult Medicine, The North West Regional Health Authority, Port of Spain, Trinidad and Tobago.
    • Coron. Artery Dis. 2017 Mar 1; 28 (2): 166-172.

    AbstractHighly active antiretroviral treatment (HAART) has considerably increased the life expectancy of patients infected with HIV. Coronary artery disease is a leading cause of mortality in patients infected with HIV. This is primarily attributed to their increased survival, HAART-induced metabolic derangements, and to HIV itself. The pathophysiology of atherosclerosis in HIV is both multifactorial and complex - involving direct endothelial injury and dysfunction, hypercoagulability, and a significant contribution from traditional cardiac risk factors. The advent of HAART has since heralded a remarkable improvement in outcomes, but at the expense of other unforeseen issues. It is thus of paramount importance to swiftly recognize and manage acute coronary syndromes in HIV-infected patients to attenuate adverse complications, which should translate into improved clinical outcomes.

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