• Johannes Grueneisen, Benedikt Michael Schaarschmidt, Martin Heubner, Saravanabavaan Suntharalingam, Ines Milk, Sonja Kinner, Antonia Heubner, Michael Forsting, Thomas Lauenstein, Verena Ruhlmann, and Lale Umutlu.
• Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, D-45147 Essen, Germany. Electronic address: Johannes.grueneisen@uk-essen.de.
• Eur J Radiol. 2015 Nov 1; 84 (11): 2097-102.

ObjectivesTo compare the diagnostic competence of FAST-PET/MRI and PET/CT for whole-body staging of female patients suspect for a recurrence of a pelvic malignancy.Methods24 female patients with a suspected tumor recurrence underwent a PET/CT and subsequent PET/MRI examination. For PET/MRI readings a whole-body FAST-protocol was implemented. Two readers separately evaluated the PET/CT and FAST PET/MRI datasets regarding identification of all tumor lesions and qualitative assessment of visual lesion-to-background contrast (4-point ordinal scale).ResultsTumor relapse was present in 21 of the 24 patients. Both, PET/CT and PET/MRI allowed for correct identification of tumor recurrence in 20 of 21 cases. Lesion-based sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy for the detection of malignant lesions were 82%, 91%, 97%, 58% and 84% for PET/CT and 85%, 87%, 96%, 63% and 86% for PET/MRI, lacking significant differences. Furthermore, no significant difference for lesion-to-background contrast of malignant and benign lesions was found.ConclusionFAST-PET/MRI provides a comparably high diagnostic performance for restaging gynecological cancer patients compared to PET/CT with slightly prolonged scan duration, yet enabling a markedly reduced radiation exposure.Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

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