• Acta haematologica · Jan 2019

    Case Reports

    Relapsed Philadelphia Chromosome-Positive Pre-B-ALL after CD19-Directed CAR-T Cell Therapy Successfully Treated with Combination of Blinatumomab and Ponatinib.

    • Firas El Chaer, Noa G Holtzman, Edward A Sausville, Jennie Y Law, Seung Tae Lee, Vu H Duong, Maria R Baer, Rima Koka, Zeba N Singh, Nancy M Hardy, and Ashkan Emadi.
    • Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
    • Acta Haematol. 2019 Jan 1; 141 (2): 107-110.

    AbstractAdults with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) treated with conventional chemotherapy have dismal outcomes. Novel immunotherapies targeting CD19, including the bispecific T-cell engager blinatumomab and chimeric antigen-receptor T (CAR-T) cells, have revolutionized the treatment of R/R B-ALL. Robust response rates to CAR-T cell therapy after blinatumomab have recently been reported, but it is unknown whether blinatumomab can be effective following failure of anti-CD19 CAR-T cell therapy. Herein, we describe a patient with Philadelphia chromosome-positive B-ALL who relapsed after CD19-directed CAR-T therapy, but subsequently responded to the combination of blinatumomab and the tyrosine kinase inhibitor ponatinib, with the achievement of a complete remission lasting 12 months.© 2018 S. Karger AG, Basel.

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