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Ann. Clin. Biochem. · Mar 1989
The influence of blood sample preparation on measured levels of morphine and its major metabolites.
- P J Hoskin, O Alsayed-Omar, G W Hanks, A Johnston, and P Turner.
- Continuing Care Unit, Royal Marsden Hospital, Sutton, Surrey, UK.
- Ann. Clin. Biochem. 1989 Mar 1; 26 ( Pt 2): 182-4.
AbstractThe effect of six different methods of blood sample preparation on concentrations of morphine (M), morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) have been investigated using a specific high performance liquid chromatography assay. No difference between glass or plastic tubes was seen in concentrations of M, M3G, or M6G; and no difference between plasma and serum in M and M6G concentrations. M3G concentrations, however, were significantly lower in plasma compared with serum. Heparin had no effect on M, M6G or M3G, whereas citrate in a glass tube produced consistently lower concentrations of M, M3G and M6G. Standardization of sample collection using plasma samples in plastic heparin tubes is recommended for future studies.
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