• Pablo Mozas, Marc Sorigué, and Armando López-Guillermo.
• Servicio de Hematología, Hospital Clínic, Barcelona, España. Electronic address: mozas@clinic.cat.
• Med Clin (Barc). 2021 Nov 12; 157 (9): 440-448.

AbstractFollicular lymphoma, the most common indolent lymphoma, originates from germinal centre B-cells of the lymphoid follicle, and is characterized by t(14;18). Clinical manifestations include the presence of lymphadenopathy, sometimes accompanied by constitutional symptoms or cytopenia. Diagnosis is established through the identification of a B-cell proliferation of nodular pattern in the lymph node biopsy. Upon staging with PET-CT and bone marrow biopsy, a significant proportion of patients do not need immediate treatment. When therapy is indicated, commonly used regimens include anti-CD20 immunotherapy with or without chemotherapy. Although overall survival for most patients is prolonged, relapses are very frequent, and early relapse and transformation to an aggressive lymphoma portend a much worse prognosis. New therapies are under development, which will most likely change outcomes for FL patients in the near future.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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