• G F Purdue, J L Hunt, J M Still, E J Law, D N Herndon, I W Goldfarb, W R Schiller, J F Hansbrough, W L Hickerson, H N Himel, G P Kealey, J Twomey, A E Missavage, L D Solem, M Davis, M Totoritis, and G D Gentzkow.
• Department of Surgery, University of Texas, Southwestern Medical Center, Dallas 75235-9031, USA.
• J Burn Care Rehabil. 1997 Jan 1; 18 (1 Pt 1): 52-7.

AbstractThis multicenter study compared the use of a biosynthetic human skin substitute with frozen human cadaver allograft for the temporary closure of excised burn wounds. Dermagraft-TC (Advanced Tissue Sciences, Inc.) (DG-TC) consists of a synthetic material onto which human neonatal fibroblasts are cultured. Burn wounds in 66 patients with a mean age of 36 years and a mean burn size of 44% total body surface area (28% total body surface area full-thickness) were surgically excised. Two comparable sites, each approximately 1% total body surface area in size, were randomized to receive either DG-TC or allograft. Both sites were then treated in the same manner. When clinically indicated (> 5 days after application) both skin replacements were removed, and the wound beds were evaluated and prepared for grafting. DG-TC was equivalent or superior to allograft with regard to autograft take at postautograft day 14. DG-TC was also easier to remove, had no epidermal slough, and resulted in less bleeding than did allograft while maintaining an adequate wound bed. Overall satisfaction was better with DG-TC.

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