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Gastroenterol. Clin. North Am. · Dec 2006
ReviewSafety of infliximab and other biologic agents in the inflammatory bowel diseases.
- Jagadeshwar G Reddy and Edward V Loftus.
- General Internal Medicine, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA.
- Gastroenterol. Clin. North Am. 2006 Dec 1; 35 (4): 837-55.
AbstractIn many ways, infliximab has drastically altered expectations for medical therapy in IBD, and it is expected that adalimumab and certolizumab pegol with ultimately have a similar role. Patients initiating such therapy should be made cognizant of the potential risks of serious infection including opportunistic ones, such as TB and histoplasmosis; demyelinating disorders; CHF; and lymphoma. Proper selection of candidates for anti-TNF-alpha therapy is critical in maintaining a proper benefit-to-risk ratio.
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