• Internal medicine · Jan 2022

    Case Reports

    Acquired Factor V Inhibitor Complicated with Immune Thrombocytopenia.

    • Fuka Mima, Ryota Minami, Mizuki Asako, Hitomi Matsunaga, Yuri Fujita, Yoshimi Takimoto, Sonoko Senda, Wataru Nakahara, Mako Ikeda, and Shuji Ueda.
    • Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Japan.
    • Intern. Med. 2022 Jan 1; 61 (1): 91-95.

    AbstractWe herein report a patient with a high bleeding tendency as a result of acquired factor V inhibitor and immune thrombocytopenia (ITP). The administration of prednisolone increased the platelet count, but a fatal bleeding event occurred before platelet levels had sufficiently increased. Factor V is stored in not only plasma but also platelets, and platelet-derived factor V might play a local hemostatic role. Bleeding tendency may be high in rare cases where factor V inhibitor is complicated with severe thrombocytopenia. In such patients, physicians should consider aggressive hemostatic therapy, including plasma exchange, in addition to immunosuppressive therapy.

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