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- Hiroyuki Sakaguchi, Azusa Tanimoto, Shigeki Sato, Naohiro Yanagimura, Chiaki Suzuki, Yohei Takumi, Akihiro Nishiyama, Kaname Yamashita, Shinji Takeuchi, Koshiro Ohtsubo, and Seiji Yano.
- Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Japan.
- Intern. Med. 2022 Jan 1; 61 (1): 75-79.
AbstractPrimary malignant melanoma (MM) of the mediastinum is rare, and there is a lack of consensus regarding the preferred treatment because non-cutaneous MM demonstrates an inferior response to systemic therapy. Herein, we describe the case of a 73-year-old man with MM of the anterior mediastinum with multiple liver metastases. Even though the size of lesions increased rapidly following diagnosis, nivolumab monotherapy caused remarkable tumor shrinkage. This is the first report of mediastinal MM showing a significant response to nivolumab. We, therefore, suggest that immunotherapy may be one of the treatment options for primary mediastinal MM.
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