• Internal medicine · Jan 2022

    Case Reports

    Trousseau's Syndrome Presenting as Multiple Cerebral Infarctions Caused by Mucin-producing Bladder Micropapillary Urothelial Cancer.

    • Sho Shimohama, Koichi Oki, Hidefumi Narita, Kyoko Mashima, Satoshi Yamada, Tomohide Adachi, Yosuke Kobayashi, Shigemichi Hirose, and Haruhiko Hoshino.
    • Department of Neurology, Tokyo Saiseikai Central Hospital, Japan.
    • Intern. Med. 2022 Jan 1; 61 (1): 97-101.

    AbstractWe herein report a 70-year-old man with recurrent multiple cerebral infarctions under warfarin therapy who was finally diagnosed with Trousseau's syndrome resulting from advanced bladder cancer. A histological examination of the mesenteric lymph nodes revealed metastasis of micropapillary urothelial cancer with positive mucin markers CA125 and MUC1. Blood examinations also indicated elevated tumor markers, such as CA19-9 and CA125. To our knowledge, this is the first report of Trousseau's syndrome in a patient with bladder micropapillary urothelial cancer in which mucin involvement was clearly proven by histological and serological examinations.

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