• Internal medicine · Feb 2022

    Case Reports

    A Combination of Indomethacin Farnesyl and Amitriptyline is Effective for Continuous Interictal Pain with Probable Chronic Paroxysmal Hemicrania.

    • Shoji Kikui, Junichi Miyahara, Hanako Sugiyama, Mutsuo Kohashi, Kuniko Ota, Daisuke Danno, Yoshihiro Kashiwaya, and Takao Takeshima.
    • Department of Neurology, Headache Center, Tominaga Hospital, Japan.
    • Intern. Med. 2022 Feb 1; 61 (3): 413-417.

    AbstractA 26-year-old woman with a history of migraine reported right-sided, severe stabbing orbital pain with cranial autonomic symptoms (CASs) for approximately 2 years. The attack duration was approximately 30 minutes, with a frequency of twice per day. Taking loxoprofen was ineffective. Six months earlier, moderate pressing continuous interictal pain without CASs had developed. Indomethacin farnesyl completely resolved the attacks but had no effect on the interictal pain. The patient was diagnosed with probable chronic paroxysmal hemicrania in accordance with the International Classification of Headache Disorders (ICHD-3) (third version). Continuous interictal pain gradually disappeared with a combination of indomethacin farnesyl and amitriptyline.

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