• Naila H Dhanani, Oscar A Olavarria, Karla Bernardi, Nicole B Lyons, Julie L Holihan, Michele Loor, Alex B Haynes, and Mike K Liang.
• McGovern Medical School at UTHealth, Houston, Texas (N.H.D., O.A.O., K.B., N.B.L., J.L.H.).
• Ann. Intern. Med. 2021 Aug 1; 174 (8): 1110-1117.

BackgroundUse of robot-assisted surgery has increased dramatically since its advent in the 1980s, and nearly all surgical subspecialties have adopted it. However, whether it has advantages compared with laparoscopy or open surgery is unknown.PurposeTo assess the quality of evidence and outcomes of robot-assisted surgery compared with laparoscopy and open surgery in adults.Data SourcesPubMed, EMBASE, Scopus, and the Cochrane Central Register of Controlled Trials were searched from inception to April 2021.Study SelectionRandomized controlled trials that compared robot-assisted abdominopelvic surgery with laparoscopy, open surgery, or both.Data ExtractionTwo reviewers independently extracted study data and risk of bias.Data SynthesisA total of 50 studies with 4898 patients were included. Of the 39 studies that reported incidence of Clavien-Dindo complications, 4 (10%) showed fewer complications with robot-assisted surgery. The majority of studies showed no difference in intraoperative complications, conversion rates, and long-term outcomes. Overall, robot-assisted surgery had longer operative duration than laparoscopy, but no obvious difference was seen versus open surgery.LimitationsHeterogeneity was present among and within the included surgical subspecialties, which precluded meta-analysis. Several trials may not have been powered to assess relevant differences in outcomes.ConclusionThere is currently no clear advantage with existing robotic platforms, which are costly and increase operative duration. With refinement, competition, and cost reduction, future versions have the potential to improve clinical outcomes without the existing disadvantages.Primary Funding SourceNone. (PROSPERO: CRD42020182027).

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