• Internal medicine · Jan 2021

    Case Reports

    Complete Response for Advanced Hepatocellular Carcinoma by Conversion Surgery Therapy Following a Good Response of Regorafenib Despite Rapid Progressive Disease with Sorafenib.

    • Kenji Yamaoka, Tomokazu Kawaoka, Hiroshi Aikata, Yuwa Ando, Yumi Kosaka, Yosuke Suehiro, Yasutomo Fujii, Shinsuke Uchikawa, Kei Morio, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Shoichi Takahashi, Yoshihiro Saeki, Shintaro Kuroda, Tsuyoshi Kobayashi, Hideki Ohdan, Yoshihiro Miyata, Morihito Okada, and Kazuaki Chayama.
    • Department of Gastroenterology and Metabolism, Research Institute for Radiation Biology and Medicine, Graduate School of Biomedical and Health Science, Hiroshima University Hospital, Japan.
    • Intern. Med. 2021 Jan 1; 60 (13): 2047-2053.

    AbstractA 68-year-old man with hepatocellular carcinoma (HCC) visited his previous hospital due to abdominal pain and was diagnosed with ruptured HCC. Before visiting our hospital, he underwent HCC treatment at his previous hospital, but his tumors did not improve. Although he started treatment with sorafenib, the tumors rapidly grew. Subsequently, regorafenib was given, and the tumors shrank. After 22 months being treated with regorafenib, HCC reoccurred, with a new lung metastasis and a contrast-enhanced nodule on the peritoneal dissemination appearing. He underwent conversion surgery and survived for 4.5 years after his HCC was diagnosed.

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