• Clin Chem Lab Med · May 1999

    Autoantibodies against oxidised low-density lipoprotein in patients with obstructive sleep apnoea.

    • S Saarelainen, T Lehtimäki, O Jaak-kola, T Poussa, M Nikkilä, T Solakivi, and M M Nieminen.
    • Department of Pulmonary Diseases, Tampere University Hospital, Pikonlinna, Finland. ssaarelainen@tays.fi
    • Clin Chem Lab Med. 1999 May 1; 37 (5): 517-20.

    AbstractAutoantibodies against oxidised low-density lipoprotein (OxLDL-Abs) have been proposed to be an indicator of endothelial dysfunction and a novel tool for finding individuals with a high cardiovascular risk. In a cross-sectional study, OxLDL-Abs were measured in 297 patients with obstructive sleep apnoea (OSA) and 54 controls using an enzyme-linked immunosorbent assay. The autoantibodies were increased in patients with OSA when compared to controls (age, body mass index (BMI) and gender adjusted, p = 0.001). However, within the OSA patients, OxLDL-Abs were not related to smoking, hypertension or BMI, and there was a weak negative correlation (r = -0.16, P = 0.007) between age and levels of OxLDL-Abs. In conclusion, at present the measurement OxLDL-Abs still remains a method for basic research and is not applicable for screening of at-risk patients with OSA.

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