• Carmel J Stock, Caterina Conti, Ángeles Montero-Fernandez, Gaetano Caramori, Philip L Molyneaux, Peter M George, Maria Kokosi, Vaslis Kouranos, Toby M Maher, Felix Chua, Alexandra Rice, Christopher P Denton, Andrew G Nicholson, Athol Wells, Piersante Sestini, and Elisabetta A Renzoni.
• Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Foundation Trust/ National Heart and Lung Institute, Imperial College, London, UK c.stock@imperial.ac.uk.
• Thorax. 2020 Oct 1; 75 (10): 901-903.

AbstractThe MUC5B promoter variant rs35705950 is associated with idiopathic pulmonary fibrosis (IPF). MUC5B glycoprotein is overexpressed in IPF lungs. We examined immunohistochemical expression of MUC5B in different interstitial lung disease patterns according to rs35705950 T-allele carriage. We observed increased expression of MUC5B in T-allele carriers in both distal airways and honeycomb cysts in patients with IPF (n=23), but no difference in MUC5B expression according to T-carrier status in the distal airways of patients with idiopathic non-specific interstitial pneumonitis (n=17), in scleroderma-associated non-specific interstitial pneumonitis (n=15) or in control lungs (n=20), suggesting that tissue overexpression in MUC5B rs35705950 T-carriers is specific to IPF.© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

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