• Support Care Cancer · Feb 2016

    Randomized Controlled Trial Multicenter Study

    Joint symptoms and health-related quality of life in postmenopausal women with breast cancer who completed 5 years of anastrozole.

    • Hiroshi Yagata, Hiroshi Ohtsu, Yoshifumi Komoike, Shigehira Saji, Hiroyuki Takei, Toshitaka Nakamura, Yasuo Ohashi, Takuya Iwase, and Kojiro Shimozuma.
    • Department of Breast Care, Saitama Medical Center, Saitama Medical University, 1981, Kamoda, Kawagoe-shi, Saitama, 350-0844, Japan. yagata@biglobe.jp.
    • Support Care Cancer. 2016 Feb 1; 24 (2): 683-689.

    PurposeTo assess the joint symptoms and the impact on patients' health-related quality of life (HRQOL) due to 5 years of anastrozole from the baseline data in the N-SAS BC 05 trial, a randomized clinical trial was designed to assess the efficacy of 5 additional years of anastrozole among women with breast cancer.MethodsJoint symptoms and HRQOL were evaluated using an original questionnaire for joint symptoms, the Short Form 36-item Health Survey (SF-36), the EuroQol EQ-5D-3L, and a subscale of the Functional Assessment of Cancer Therapy-Endocrine Symptoms (FACT-ES).ResultsBaseline joint symptom and HRQOL data were collected from 330 patients between November 2007 and March 2010. Joint pain and joint stiffness were reported by 61.6 and 59.1 % of patients, respectively, although these symptoms did not affect the activities of daily living in 96.0 and 97.9 % of patients, respectively. Joint pain was reported in the knee by 61.0 % of patients and in the hand by 36.0 % of patients. Joint stiffness mainly affected the hand (67.9 %), especially the proximal interphalangeal joint, and typically occurred upon waking up or in the morning. Most SF-36 domains had good average scores, although slight decreases in physical functioning and role-physical were observed (compared to the national standard scores). The mean EQ-5D utility score was 0.86, and the total FACT-ES subscale score was 62.2/76.ConclusionsAfter 5 years of anastrozole, many of the patients reported joint pain and stiffness in mainly the hand and knee with mild symptoms and good HRQOL.

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