• Fumikata Hara, Sachiko Kiyoto, Mina Takahashi, Daisuke Takabatake, Seiki Takashima, Kenjiro Aogi, Shozo Ohsumi, and Shigemitsu Takashima.
• Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan. hfumikat@shikoku-cc.go.jp
• Oncology. 2010 Jan 1; 79 (3-4): 273-7.

BackgroundIt is extremely difficult to bring about a complete cure of metastatic breast cancer: the purpose of treatment is to prolong the patient's survival while maintaining their quality of life (QOL). The current retrospective study was conducted to find whether S-1, an orally administered 5-FU agent, can produce a therapeutic result in patients with recurrent metastatic breast cancer while maintaining their QOL.MethodsAmong the patients who were diagnosed at our institution to have recurrent metastatic breast cancer between November 2001 and December 2008, those who were treated with S-1 were selected and their records retrospectively reviewed.ResultsThe analysis was conducted on 33 patients. The median number of regimens that these patients underwent was 2 (range 0-6). The overall response rate (ORR), clinical benefit rate (CBR), median time to treatment failure and overall survival were 30%, 42%, 152 days and 338 days, respectively. Among the 11 patients who were treated with S-1 in the first or the second line, ORR and CBR were 45.5 and 63.6%, respectively. Toxicity more than grade 3, leucopenia, neutropenia diarrhea, mucositis, and hand-foot syndrome were found in only 3%.ConclusionS-1 is well-tolerated by patients, promising a therapy while maintaining their QOL. When applied in the early stage of a disease in particular, the agent promises a very effective anti-tumor effect.Copyright © 2011 S. Karger AG, Basel.

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