• Neurosurg. Clin. N. Am. · Oct 2018

    Review

    Management of Intracranial Hemorrhage in the Anticoagulated Patient.

    • MacdonaldRobert LochRLDivision of Neurosurgery, Department of Surgery, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Mich.
    • Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada; Department of Physiology, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada. Electronic address: macdonaldlo@smh.ca.
    • Neurosurg. Clin. N. Am. 2018 Oct 1; 29 (4): 605-613.

    AbstractAntiplatelet and anticoagulant drugs (antithrombotic drugs) can cause or be associated with intracranial hemorrhage. Patients who take antithrombotic drugs are at higher risk for intracranial hemorrhage after trauma and are neurologically worse acutely compared with patients not on antithrombotic drugs. Treatment of patients on antithrombotic drugs who have intracranial hemorrhage includes reversal of anticoagulant drugs in almost all cases. This article is a synopsis of the data pertaining to intracranial hemorrhage and antithrombotic drugs and methods to diagnose the pharmacologic effects and to reverse the effects of these drugs in patients with traumatic or spontaneous intracranial hemorrhage.Copyright © 2018 Elsevier Inc. All rights reserved.

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