• Annals of neurology · Aug 2007

    Cystatin C in cerebrospinal fluid and multiple sclerosis.

    • Sara F Hansson, SimonsenAnja HviidAH, Henrik Zetterberg, Oluf Andersen, Sara Haghighi, Inger Fagerberg, Ulf Andréasson, Ann Westman-Brinkmalm, Anders Wallin, Ulla Rüetschi, and Kaj Blennow.
    • Department of Clinical Neuroscience, University of Göteborg, Sahlgrenska University Hospital/Mölndal, Mölndal, Sweden.
    • Ann. Neurol. 2007 Aug 1; 62 (2): 193-6; discussion 205.

    ObjectiveA recent study using surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid identified a 12.5 kDa truncated isoform of cystatin C (CysC) as a specific biomarker for multiple sclerosis (MS).MethodsSurface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid samples from 43 MS patients and 46 healthy control subjects.ResultsFull-length CysC (13.4 kDa) concentration was similar in MS and control samples. The 12.5 kDa CysC protein was produced from full-length CysC by N-terminal cleavage during storage at -20 degrees C.InterpretationThe 12.5 kDa CysC isoform is a storage-related artifact and is not useful as a diagnostic marker for MS.

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